BROT Sébastien

Publications HAL

Article dans une revue (14 documents)

Bérengère Ballion, Marie-Laure Bonnet, Sébastien Brot, Afsaneh Gaillard. Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson’s disease. Current Stem Cell Research & Therapy, 2025, 16 (1), pp.232. ⟨10.1186/s13287-025-04344-z⟩. ⟨hal-05063750⟩
Maëlig Patrigeon, Sébastien Brot, Marie-Laure Bonnet, Laure Belnoue, Afsaneh Gaillard. Host-to-graft Propagation of α-synuclein in a Mouse Model of Parkinson’s Disease: Intranigral Versus Intrastriatal Transplantation. Transplantation, 2023, 107 (8), p. 201-212. ⟨10.1097/TP.0000000000004565⟩. ⟨hal-04132835⟩
Amandine Desette, Pierre-Olivier Guichet, Sheik Emambux, Konstantin Masliantsev, Ulrich Cortes, et al.. Deciphering Brain Metastasis Stem Cell Properties From Colorectal Cancer Highlights Specific Stemness Signature and Shared Molecular Features. Cellular and Molecular Gastroenterology and Hepatology, 2023, 16 (5), pp.757-782. ⟨10.1016/j.jcmgh.2023.07.008⟩. ⟨hal-04302791⟩
Anaïs Lainé, Sébastien Brot, Afsaneh Gaillard. Beneficial Effects of Hyaluronan-Based Hydrogel Implantation after Cortical Traumatic Injury. Cells, 2022, 11 (23), pp.3831. ⟨10.3390/cells11233831⟩. ⟨hal-04132825⟩
Sébastien Brot, Nabila Pyrenina Thamrin, Marie-Laure Bonnet, Maureen Francheteau, Maëlig Patrigeon, et al.. Long-Term Evaluation of Intranigral Transplantation of Human iPSC-Derived Dopamine Neurons in a Parkinson’s Disease Mouse Model. Cells, 2022, 11 (10), pp.1596. ⟨10.3390/cells11101596⟩. ⟨hal-03682097⟩
Marine Droguerre, Sébastien Brot, Clément Vitrac, Marianne Benoit-Marand, Laure Belnoue, et al.. Better Outcomes with Intranigral versus Intrastriatal Cell Transplantation: Relevance for Parkinson’s Disease. Cells, 2022, 11 (7), ⟨10.3390/cells11071191⟩. ⟨hal-03637153⟩
Stéphanie Pain, Sébastien Brot, Afsaneh Gaillard. Neuroprotective effects of neuropeptide Y against neurodegenerative disease. Current Neuropharmacology, 2021, 19, ⟨10.2174/1570159X19666210906120302⟩. ⟨hal-03361423⟩
Nissrine Ballout, Tristan Rochelle, Sébastien Brot, Marie-Laure Bonnet, Maureen Francheteau, et al.. Characterization of Inflammation in Delayed Cortical Transplantation. Frontiers in Molecular Neuroscience, 2019, 12, ⟨10.3389/fnmol.2019.00160⟩. ⟨hal-02498268⟩
Sophie Péron, Marine Droguerre, Franck Debarbieux, Nissrine Ballout, Marianne Benoit-Marand, et al.. A Delay between Motor Cortex Lesions and Neuronal Transplantation Enhances Graft Integration and Improves Repair and Recovery. Journal of Neuroscience, 2017, 37 (7), pp.1820-1834. ⟨10.1523/JNEUROSCI.2936-16.2017⟩. ⟨hal-02500429⟩
Sébastien Brot, Hinda Smaoune, Mina Youssef-Issa, Céline Malleval, Claire Benetollo, et al.. Collapsin response-mediator protein 5 (CRMP5) phosphorylation at threonine 516 regulates neurite outgrowth inhibition. European Journal of Neuroscience, 2014, 40 (7), pp.3010-3020. ⟨10.1111/ejn.12674⟩. ⟨hal-02511291⟩
Sébastien Brot, Carole Auger, Rabia Bentata, Véronique Rogemond, Stéphane Ménigoz, et al.. Collapsin Response Mediator Protein 5 (CRMP5) Induces Mitophagy Thereby Regulating Mitochondrion Numbers in Dendrites.. Journal of Biological Chemistry, 2013, 289, pp.2261-2276. ⟨10.1074/jbc.M113.490862⟩. ⟨hal-00917349⟩
Dominique Bétemps, Jérémy Verchère, Sébastien Brot, Eric Morignat, Luc Bousset, et al.. Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA. Acta Neuropathologica Communications, 2013, 2, pp.29. ⟨10.1186/2051-5960-2-29⟩. ⟨hal-01183383⟩
Sébastien Brot, Céline Malleval, Claire Benetollo, Carole Auger, David Meyronet, et al.. Identification of a new CRMP5 isoform present in the nucleus of cancer cells and enhancing their proliferation. Experimental Cell Research, 2013, 319 (5), pp.588-599. ⟨10.1016/j.yexcr.2012.12.011⟩. ⟨hal-02511307⟩
Sébastien Brot, Véronique Rogemond, Valérie Perrot, Naura Chounlamountri, Carole Auger, et al.. CRMP5 Interacts with Tubulin to Inhibit Neurite Outgrowth, Thereby Modulating the Function of CRMP2. Journal of Neuroscience, 2010, 30 (32), pp.10639-10654. ⟨10.1523/JNEUROSCI.0059-10.2010⟩. ⟨hal-02351827⟩

Poster (37 documents)

Laure Belnoue, Maëlig Patrigeon, Marie-Laure Bonnet, Sébastien Brot, Afsaneh Gaillard. Transplantation of iPSC-derived dopamine neurons in alpha-synuclein overexpression mouse model. NeuroFrance 2023, May 2023, Lyon, France. ⟨hal-05008254⟩
Bérengère Ballion, Marie-Laure Bonnet, Sébastien Brot, Afsaneh Gaillard. Functional integration of grafted hiPSC derived dopamine neurons in a mouse model of Parkinson's disease. NeuroFrance 2023, May 2023, Lyon, France. ⟨hal-05093772⟩
Maëlig Patrigeon, Sébastien Brot, Marie-Laure Bonnet, Laure Belnoue, Afsaneh Gaillard. Host to graft propagation of alpha-synuclein in Parkinson’s disease: intra-nigral versus intra-striatal transplantation. 13th FENS Forum of Neuroscience, Jul 2022, Paris, France. ⟨hal-05008798⟩
Sébastien Brot, Marie-Laure Bonnet, Bérangère Ballion, Maëlig Patrigeon, Maureen Francheteau, et al.. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. 13th FENS Forum of Neuroscience, Jul 2022, Paris, France. ⟨hal-05008791⟩
Bérangère Ballion, Sébastien Brot, Laure Belnoue, Afsaneh Gaillard. Functional integration of intranigral grafted hiPSC derived dopamine neurons in a mouse model of Parkinson disease. FENS Forum 2022, Jul 2022, Paris, France. . ⟨hal-04517426⟩
Oriane Rabesandratana, Anaïs Lainé, Marie-Laure Bonnet, Laure Belnoue, Sébastien Brot, et al.. Biomaterials to enhance the integration of grafted human iPSC-derived motor cortical neurons in a mice model of traumatic injury. FSSCR annual meeting 2021, Nov 2021, Montpellier, France. ⟨hal-03489108⟩
Sébastien Brot, Marie-Laure Bonnet, Bérangère Ballion, Maëlig Patrigeon, Maureen Francheteau, et al.. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. 31st Annual meeting of the Network for European CNS Transplantation and Restoration (NECTAR), Nov 2021, Edinburg, United Kingdom. ⟨hal-05008766⟩
Sébastien Brot, Marie-Laure Bonnet, Bérangère Ballion, Maëlig Patrigeon, Maureen Francheteau, et al.. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. 31st Annual meeting of the Network for European CNS Transplantation and Restoration (NECTAR), Nov 2021, Edinburgh, France. . ⟨hal-03637185⟩
Bérangère Ballion, Laure Belnoue, Sébastien Brot, Afsaneh Gaillard. Functional integration of grafted hiPSC derived dopamine neurons in a murine model of Parkinson's disease. NeuroFrance 2021, May 2021, Strasbourg, France. ⟨hal-03405614⟩
Maëlig Patrigeon, Sébastien Brot, Marie-Laure Bonnet, Laure Belnoue, Afsaneh Gaillard. Host to graft propagation of α-synuclein in Parkinson’s disease: intra-nigral versus intra-striatal transplantation.. NeuroFrance 2021, May 2021, Strasbourg, France. ⟨hal-03221475⟩
Laure Belnoue, Hammam I. El Hajj, Marie-Laure Bonnet, Sébastien Brot, Afsaneh Gaillard. The potential of motor cortical neurons derived hiPSC transplantation for brain repair following traumatic brain injury. NeuroFrance 2021, May 2021, Strasbourg, France. ⟨hal-03221118⟩
Nabila Pyrenina Thamrin, Marie-Laure Bonnet, Maëlig Patrigeon, Laure Belnoue, Jean Christophe C Corvol, et al.. Modelling Parkinson´s disease with patient induced pluripotent stem cells. NeuroFrance 2021, May 2021, Strasbourg, France. ⟨hal-03221486⟩
Anaïs Lainé, Sébastien Brot, Oriane Rabesandratana, Afsaneh Gaillard. Therapeutic effects of hyaluronan-based hydrogel after cortical traumatic injury. NeuroFrance 2021, May 2021, Strasbourg, France. ⟨hal-03221468⟩
Sébastien Brot, Marie-Laure Bonnet, Maëlig Patrigeon, Maureen Francheteau, Laure Belnoue, et al.. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. NeuroFrance 2021, May 2021, Strasbourg, France. ⟨hal-03221124⟩
Sébastien Brot, Marie-Laure Bonnet, Maureen Francheteau, Laure Belnoue, Afsaneh Gaillard. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. PHysiopathology Of Parkinson’s disEase » (HOPE), Jan 2020, Paris, France. ⟨hal-02511393⟩
Sébastien Brot, Marie-Laure Bonnet, Maureen Francheteau, Afsaneh Gaillard. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. From 3D culture to organoïds - AVIESAN, Dec 2019, Paris, France. ⟨hal-02512008⟩
Sébastien Brot, Marie-Laure Bonnet, Maureen Francheteau, Afsaneh Gaillard. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. FSSCR 3rd Annual Meeting, Nov 2019, Lyon, France. ⟨hal-02512692⟩
Hammam L El Hajj, Laure Belnoue, Marie-Laure Bonnet, Sébastien Brot, Afsaneh Gaillard. The potential of motor cortical neurons derived hiPSC transplantation for brain repair following traumatic brain injury. Neurofrance, Jun 2019, Marseille, France. ⟨hal-02516060⟩
Anaïs Lainé, Nissrine Ballout, Marie Droguerre, Sébastien Brot, Maureen Francheteau, et al.. Absence of interleukin 33 impaired axonal outgrowth of grafted cortical neurons.. NeuroFrance, the international conference of the french society of Neuroscience, May 2019, Marseille, France. ⟨hal-02547007⟩
Sébastien Brot, Marie-Laure Bonnet, Maureen Francheteau, Afsaneh Gaillard. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. LE STUDIUM CONFERENCE : Induced Pluripotent Stem Cells (iPSCs): From Disease Models to Mini-Organs, Jan 2019, Tours, France. ⟨hal-02512709⟩
Sébastien Brot, Marie-Laure Bonnet, Maureen Francheteau, Afsaneh Gaillard. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. 11th FENS Forum of Neuroscience, Jul 2018, Berlin, Germany. ⟨hal-02512713⟩
Hammam L El Hajj, Sébastien Brot, Marie-Laure Bonnet, Afsaneh Gaillard. Differentiation of human iPSC into neurons of motor cortex and grafting into injured motor cortex of adult mice. 11th FENS forum of Neurosciences, Jul 2018, Berlin, Germany. ⟨hal-02516097⟩
Sébastien Brot, Marie-Laure Bonnet, Maureen Francheteau, Afsaneh Gaillard. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. Symposium "(Re)Constructing the nervous system: stem cells and beyond" Institut fer à Moulin, Sep 2017, Paris, France. ⟨hal-02516028⟩
Sébastien Brot, Marie-Laure Bonnet, Maureen Francheteau, Afsaneh Gaillard. Dopamine neurons derived from human induced pluripotent stem cell reprogrammed by mRNA. Neurofrane, May 2017, Bordeaux, France. ⟨hal-02516038⟩
Nissrine Ballout, Tristan Rochelle, Sébastien Brot, Maureen Francheteau, Jean-Marc Gombert, et al.. Beneficial effects of inflammation in delayed cortical transplantation. Neurofrance, May 2017, Bordeaux, France. ⟨hal-02517467⟩
Nissrine Ballout, Tristan Rochelle, Sébastien Brot, Maureen Francheteau, Jean-Marc Gombert, et al.. Study of Neuroinflammation after cortical lesion and transplantation with or without delay. Plasticité cérébrale, de la recherche fondamentale à la clinique 2e Journées Thématiques de la société des Neurosciences, May 2016, Tours, France. ⟨hal-02517855⟩
Sandie Brisson, Bhaskar Saha, Tristan Rochelle, Sébastien Brot, Marie-Laure Bonnet, et al.. Production and characterization of dopaminergic neurons derived from mouse embryonic stem cells. Plasticité cérébrale, de la recherche fondamentale à la clinique - 2e Journées Thématiques de la société des neurosciences, May 2016, Tours, France. ⟨hal-02517846⟩
Obélia Haida, Tareq Al Sagheer, Anais Balbous, Sébastien Brot, Maureen Francheteau, et al.. Molecular and cellular alterations underlying motor disorders in autism spectrum disorders mouse models. Séminaire thématique bio-santé ED 524, Mar 2016, Pouligny-Notre-Dame, France. ⟨hal-02556995⟩
Sébastien Brot, Sandie Brisson, Bhaskar Saha, Tristan Rochelle, Marie-Laure Bonnet, et al.. Production and characterization of dopaminergic neurons derived from mouse embryonic stem cells. 3ème Journée Scientifique de la SFR Tours-Poitiers, Jun 2015, Tours, France. ⟨hal-02517803⟩
Nissrine Ballout, Tristan Rochelle, Sébastien Brot, Maureen Francheteau, Jean-Marc Gombert, et al.. Study of Neuroinflammation after cortical lesion and transplantation with or without delay. 12e colloque de la société des Neurosciences, May 2015, Montpellier, France. ⟨hal-02517504⟩
Afsaneh Gaillard, Sophie Péron, Marine Droguerre, Nissrine Ballout, Sébastien Brot, et al.. Delaying cortical transplantation improves the outcome of the graft. 9th FENS Forum of Neuroscience, Jul 2014, Milan, Italy. ⟨hal-02517797⟩
Tristan Rochelle, Sandie Brisson, Sébastien Brot, Marie-Laure Bonnet, Marine Droguerre, et al.. Nigrostriatal pathway reconstruction by transplanting embryonic stem cell-derived dopaminergic neurons in Parkinson’s disease. 2ème Journée Scientifique de la SFR Tours-Poitiers, Jun 2014, Poitiers, France. ⟨hal-02517734⟩
Sandie Brisson, Bhaskar Saha, Tristan Rochelle, Sébastien Brot, Marie-Laure Bonnet, et al.. Production and characterization of dopaminergic neurons derived from mouse embryonic stem cells. Journée de recherche Tours-Poitiers-Limoges, Jan 2014, Tours, France. ⟨hal-02517712⟩
Sébastien Brot, Carole Auger, Véronique Rogemond, Jérome Honnorat, Mahnaz Moradi-Améli. Collapsin Response Mediator Protein 5, a multifunction protein involved in neuronal polarity and mitochondrial machinery. 7th FENS Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands. ⟨hal-02518829⟩
Sébastien Brot, Claire Benetollo, Celine Malleval, Jérome Honnorat. Differential localization of CRMP5 in cancer cells compared to normal condition. 5ème journée scientifique du CLARA "Cancéropôle Lyon Auvergne Rhône-Alpes", Mar 2010, Lyon, France. ⟨hal-02518843⟩
Sébastien Brot, Véronique Rogemond, Valérie Perrot, Naura Chounlamountri, Carole Auger, et al.. Identification of a direct interaction between CRMP5 and tubulin involved in neurite outgrowth inhibition. 9ème Colloque de la société des Neurosciences, May 2009, Bordeaux, France. ⟨hal-02518885⟩
Sébastien Brot, Celine Malleval, Jérome Honnorat, Mahnaz Moradi-Améli. Study of CRMP5 properties and its role in the development of cerebral tumors. 3ème journée scientifique du CLARA "Cancéropôle Lyon Auvergne Rhône-Alpes", Mar 2008, Lyon, France. ⟨hal-02518895⟩

Communication dans un congrès (2 documents)

Sébastien Brot. Potential of dopamine neurons derived from human induced pluripotent stem cells reprogrammed by mRNA for Parkinson’s disease. PHysiopathology Of Parkinson’s disEase » (HOPE), Jan 2020, Paris, France. ⟨hal-02511362⟩
Sébastien Brot. La reprogrammation d’hiPSC par ARNm, une nouvelle approche pour la transplantation de neurones dopaminergiques. Journée scientifique SFR FED 4226 Neuroimagerie Fonctionnelle, Jun 2017, Poitiers, France. ⟨hal-02511347⟩

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