Peer-reviewed Articles

2026

  • Nadal-Gratacós N, Pain S, Mata S, Puigseslloses P, de Macedo M, Lardeux V, Wang F-H, Källsten L, Pubill D, Berzosa X, Kehr J, Solinas M, Escubedo E, Camarasa J, López-Arnau R. Pharmacological characterization of 4-F-3-Me-α-PVP: A novel synthetic cathinone with psychostimulant effects and abuse liability in rodents. J Psychopharmacol. 2026 Mar;2698811261430492. doi: 10.1177/02698811261430492.
  • Pain S, Nadal-Gratacós N, de Macedo M, Lardeux V, Mata S, Puigseslloses P, Wang F-H, Källsten L, Pubill D, Berzosa X, Kehr J, Camarasa J, Escubedo E, López-Arnau R, Thiriet N, Solinas M. Neurochemical and Behavioral Evidence of High Abuse Liability of 3F-NEB, a Novel Synthetic Cathinone. Eur J Pharmacol. 2026 Jan;178570. doi: 10.1016/j.ejphar.2026.178570.
  • Nadal-Gratacós N, Mata S, Puigseslloses P, de Macedo M, Lardeux V, Pain S, Wang F-H, Källsten L, Pubill D, Berzosa X, Kehr J, Solinas M, Camarasa J, Escubedo E, López-Arnau R. Unveiling the potential abuse liability of α-D2PV: A novel α-carbon phenyl-substituted synthetic cathinone. Neuropharmacology. 2025 Jul;272:110425. doi: 10.1016/j.neuropharm.2025.110425.
  • Belujon P, Lardeux V, Dugast E, Serrière S, Bodard S, Busson J, Tauber C, Galineau L, Solinas M. Environmental enrichment selectively restores brain metabolic activity during cocaine abstinence. Preprint. 2025 Nov. HAL Id: inserm-05348318.
  • Magnard R, Cheng Y, Zhou J, Province H, Thiriet N, Janak PH, Vandaele Y. Sequence termination cues drive habits via dopamine-mediated credit assignment. Preprint. 2026 Jan. doi: 10.1101/2024.10.16.618735.

2025

  • Nadal-Gratacós N, Puigseslloses P, Guzmán L, Weiss N, Pottie E, Riera-Colomer C, Lardeux V, Thiriet N, Wang F-H, Källsten L, Pérez-Esteban I, Ketsela G, Margall J, Berzosa X, Pubill D, Rodríguez-Arias M, Ettcheto M, Kehr J, Stove C, Solinas M, Sitte H, Escubedo E, López-Arnau R. The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents. Mol Psychiatry. 2025 Nov;31(4):1909-1922. doi: 10.1038/s41380-025-03341-1.
  • Dorémus L, Dugast E, Delafenêtre A, Delouche M, Aupy T, Bernard O, Sebille S, Thiriet N, Piquereau J. Optimization of permeabilized brain tissue preparation to improve the analysis of mitochondrial oxidative capacities in specific subregions of the rat brain. J Neurosci Methods. 2025 Apr;416:110387. doi: 10.1016/j.jneumeth.2025.110387.
  • Gauthier M, Hebert LP, Dugast E, Lardeux V, Letort K, Thiriet N, Belnoue L, Balado E, Solinas M, Belujon P. Sex-dependent effects of stress on aIC-NAc circuit neuroplasticity: Role of the endocannabinoid system. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Apr;138:111335. doi: 10.1016/j.pnpbp.2025.111335.
  • Carr M, van Mourik Y, Gómez-Sotres P, Solinas M, de Vries T, Pattij T. Assessment of impulsivity using an automated, self-adjusting delay discounting procedure. Behav Brain Res. 2025 Mar;480:115405. doi: 10.1016/j.bbr.2024.115405.
  • Barillot L, Chauvet C, Chauchard E, Besnier M, Harika-Germaneau G, Noël X, Jaafari N, Solinas M, Chatard A. Moving beyond animal models: enriched environments and human substance use disorders. Front Behav Neurosci. 2025 Sep;19:1629918. doi: 10.3389/fnbeh.2025.1629918.

2024

  • Wahab M, Mead N, Desmercieres S, Lardeux V, Dugast E, Baumeister R, Solinas M. Cognitive effort increases the intensity of rewards. PNAS Nexus. 2024 Oct;3(10):pgae432. doi: 10.1093/pnasnexus/pgae432.
  • Solinas M, Melis M. Developmental exposure to cannabis compromises dopamine system function and behavior. Curr Opin Behav Sci. 2024 Oct;59:101442. doi: 10.1016/j.cobeha.2024.101442.
  • Solinas M, Chauvet C, Lafay-Chebassier C, Vanderkam P, Barillot L, Moeller SJ, Goldstein R, Noël X, Jaafari N, Chatard A. Tobacco Images Choice and Its Association with Craving and Dependence in People who Smoke Cigarettes. Nicotine Tob Res. 2024 Jun;26(12):1636-1645. doi: 10.1093/ntr/ntae138.
  • Desmercieres S, Lardeux V, Longueville J-E, Dugast E, Thiriet N, Solinas M. Effects of Highly Palatable Diet on motivation for food and resistance to punishment in rats: Role of sex and age of exposure. Appetite. 2024 Apr;198:107340. doi: 10.1016/j.appet.2024.107340.
  • Solinas M, Lardeux V, Leblanc P-M, Longueville J-E, Thiriet N, Vandaele Y, Panlilio L, Jaafari N. Delay of punishment highlights differential vulnerability to developing addiction-like behavior toward sweet food. Transl Psychiatry. 2024 Mar;14(1):155. doi: 10.1038/s41398-024-02863-6.
  • Brunault P, Ingrand I, Solinas M, Dugast E, Pérault-Pochat M-C, Ingrand P, Vanderkam P, Lafay-Chebassier C. Smokers with higher positive or negative urgency have lower rates of smoking cessation success 12 months after a quit attempt. Sci Rep. 2024 May;14(1):12321. doi: 10.1038/s41598-024-62972-6.
  • Barillot L, Chauvet C, Besnier M, Jaafari N, Solinas M, Chatard A. Effect of environmental enrichment on relapse rates in patients with severe alcohol use disorder: protocol for a randomised controlled trial. BMJ Open. 2023 May;13(5):e069249. doi: 10.1136/bmjopen-2022-069249.
  • Vandaele Y, Janak PH. Lack of action monitoring as a prerequisite for habitual and chunked behavior: Behavioral and neural correlates. iScience. 2023 Jan;26(1):105818. doi: 10.1016/j.isci.

2023

  • Gauthier M, Dugast E, Lardeux V, Letort K, Belnoue L, Balado E, Solinas M, Belujon P. Sex-dependent effects of stress on insular cortex-to-nucleus accumbens synaptic plasticity. Preprint. 2023 Oct. doi: 10.1101/2023.08.28.555067.
  • Solinas M, Chauvet C, Lafay-Chebassier C, Vanderkam P, Barillot L, Moeller S, Goldstein R, Noël X, Jaafari N, Chatard A. Cue-Induced Drug Seeking and Its Association with Craving and Dependence in Cigarette Smokers. Preprint. 2023 Oct. doi: 10.1101/2023.08.30.555462.
  • Salin A, Dugast E, Lardeux V, Solinas M, Belujon P. The amygdala-ventral pallidum pathway contributes to a hypodopaminergic state in the ventral tegmental area during protracted abstinence from chronic cocaine. Br J Pharmacol. 2023 Jan;180(14):1819-1831. doi: 10.1111/bph.16034.
  • Thabault M, Turpin V, Balado E, Fernandes-Gomes C, Huot AL, Cantereau A, Fernagut PO, Jaber M, Galvan L. Age-related behavioral and striatal dysfunctions in Shank3 mouse model of autism spectrum disorder. Eur J Neurosci. 2023 Jan 19. doi: 10.1111/ejn.15919.

2022

  • Nicolas C, Hofford RS, Dugast E, Lardeux V, Belujon P, Solinas M, Bardo MT, Thiriet N. Prevention of relapse to methamphetamine self-administration by environmental enrichment: involvement of glucocorticoid receptors.Psychopharmacology (Berl). 2022 Apr;239(4):1009-1018. doi: 10.1007/s00213-021-05770-6. Epub 2021 Mar 25. PMID: 33768375
  • Droguerre M, Brot S, Vitrac C, Benoit-Marand M, Belnoue L, Patrigeon M, Lainé A, Béré E, Jaber M, Gaillard A. Better Outcomes with Intranigral versus Intrastriatal Cell Transplantation : Relevance for Parkinson’s Disease. Cells. 2022 Apr 1;11(7):1191. doi: 10.3390/cells11071191.
  • Desmercieres S, Lardeux V, Longueville JE, Hanna M, Panlilio LV, Thiriet N, Solinas M. A self-adjusting, progressive shock strength procedure to investigate resistance to punishment: Characterization in male and female rats. Neuropharmacology. 2022 Dec 1;220:109261. doi: 10.1016/j.neuropharm.2022.109261. Epub 2022 Sep 22. PMID: 36152690 Free article.
  • Harika-Germaneau G, Langbour N, Patri S, Solinas M, Chatard A, Millet B, Hashemian F, Pérault-Pochat MC, Jaafari N, Lafay-Chebassier Impact of brain-derived neurotrophic factor Val66Met polymorphism and response to escitalopram or paroxetine in obsessive-compulsive disorder. CNS Spectr. 2022 Oct;27(5):645-651. doi: 10.1017/S1092852921000687. Epub 2021 Jul 27.PMID: 34313207
  • Maisterrena A, Matas E, Mirfendereski H, Balbous A, Marchand S, Jaber M. The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder. Biomolecules. 2022 Nov 15;12(11):1691. doi: 10.3390/biom12111691.
  • Thabault M, Turpin V, Maisterrena A, Jaber M, Egloff M, Galvan L. Cerebellar and Striatal Implications in Autism Spectrum Disorders: From Clinical Observations to Animal Models. Int J Mol Sci. 2022 Feb 18;23(4):2294. doi: 10.3390/ijms23042294.
  • Jaber M. Genetic and environmental mouse models of autism reproduce the spectrum of the disease. J Neural Transm (Vienna). 2022 Nov 1. doi:10.1007/s00702-022-02555-9.

2021

  • Nicolas C, Hofford RS, Dugast E, Lardeux V, Belujon P, Solinas M, Bardo MT, Thiriet N. Prevention of relapse to methamphetamine self-administration by environmental enrichment: involvement of glucocorticoid receptors. Psychopharmacology (Berl). 2021 Mar 25. doi: 10.1007/s00213-021-05770-6. Epub ahead of print. PMID: 33768375.
  • Solinas M, Chauvet C, Lafay-Chebassier C, Jaafari N, Thiriet N. Environmental enrichment-inspired pharmacological tools for the treatment of addiction. Curr Opin Pharmacol. 2021 Feb;56:22-28. doi: 10.1016/j.coph.2020.09.001. Epub 2020 Sep 20. PMID: 32966941.
  • Salin A, Lardeux V, Solinas M, Belujon P. Protracted Abstinence From Extended Cocaine Self-Administration Is Associated With Hypodopaminergic Activity in the VTA but Not in the SNc. Int J Neuropsychopharmacol. 2021 Jul 14;24(6):499-504. doi: 10.1093/ijnp/pyaa096. PMID: 33305794; PMCID: PMC8278795.

2020

  • Salin A, Lardeux V, Solinas M, Belujon P. Protracted abstinence from extended cocaine self-administration is associated with hypodopaminergic activity in the VTA but not in the SNc. Int J Neuropsychopharmacol. 2020 Dec 11:pyaa096. doi: 10.1093/ijnp/pyaa096. Epub ahead of print. PMID: 33305794.
  • Solinas M, Chauvet C, Lafay-Chebassier C, Jaafari N, Thiriet N. Environmental enrichment-inspired pharmacological tools for the treatment of addiction. Curr Opin Pharmacol. 2020 Sep 20;56:22-28. doi: 10.1016/j.coph.2020.09.001. Epub ahead of print. PMID: 32966941.
  • Vanderkam P, Solinas M, Ingrand I, Doux N, Ebrahimighavam S, Jaafari N, Lafay-Chebassier C. Effectiveness of drugs acting on adrenergic receptors in the treatment for tobacco or alcohol use disorders: systematic review and meta-analysis. Addiction. 2020 Sep 22. doi: 10.1111/add.15265. Epub ahead of print. PMID: 32959918.
  • Dandaba M, Serra W, Harika-Germaneau G, Silvain C, Langbour N, Solinas M, Noël X, Jaafari N, Chatard A. Predicting relapse in patients with severe alcohol use disorder: The role of alcohol insight and implicit alcohol associations. Addict Behav. 2020 Aug;107:106433. doi: 10.1016/j.addbeh.2020.106433. Epub 2020 Apr 7. PMID: 32289744.

2018

  • Alsebaaly J, Dugast E, Favot L, Rabbaa Khabbaz L, Solinas M, Thiriet N. Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats. Front Mol Neurosci. 2018 Dec 13;11:457. doi: 10.3389/fnmol.2018.00457. eCollection 2018.
  • Wahab M, Panlilio LV, Solinas M. An improved within-session self-adjusting delay discounting procedure for the study of choice impulsivity in rats. Psychopharmacology (Berl). 2018 Jul;235(7):2123-2135. doi: 10.1007/s00213-018-4911-y. Epub 2018 Apr 30
  • Ingrand I, Solinas M, Ingrand P, Dugast E, Saulnier PJ, Pérault-Pochat MC, Lafay-Chebassier C.« Lack of effects of simvastatin on smoking cessation in humans: A double-blind, randomized, placebo-controlled clinical study. Sci Rep. 2018 Mar 1;8(1):3836. doi: 10.1038/s41598-018-21819-7

2017

  • Sikora M, Nicolas C, Istin M, Jaafari N, Thiriet N, Solinas M. Generalization of effects of environmental enrichment on seeking for different classes of drugs of abuse. Behav Brain Res. 2018 Apr 2;341:109-113. doi: 10.1016/j.bbr.2017.12.027. Epub 2017 Dec 27
  • Nicolas C, Tauber C, Lepelletier FX, Chalon S, Belujon P, Galineau L, Solinas M. « Longitudinal Changes in Brain Metabolic Activity after Withdrawal from Escalation of Cocaine Self-Administration. 2017 Sep;42(10):1981-1990. doi: 10.1038/npp.2017.109. Epub 2017 May 29.
  • Lafragette A, Bardo MT, Lardeux V, Solinas M, Thiriet N. Reduction of Cocaine-Induced Locomotor Effects by Enriched Environment Is Associated with Cell-Specific Accumulation of ΔFosB in Striatal and Cortical Subregions. Int J Neuropsychopharmacol. 2017 Mar 1;20(3):237-246. doi: 10.1093/ijnp/pyw097.

 

2016

  • Chauvet C, Nicolas C, Lafay-chebassier C, Jaber M, Thiriet N, Solinas M. Statins reduce the risks of relapse to addiction in rats Neuropsychopharmacology 2016 May ;41(6) :1588-97
  • Istin M, Thiriet N, Solinas M Behavioral flexibility predicts increased ability to resist excessive methamphetamine self-administration Addict Biol 2016 Mar 9
  • Nicolas C, Lafay-Chebassier, Solinas M exposure to sucrose during periods of withdrawal does not reduce cocaine-seeking in rats Scientific Report 2016 Mar21 ;6 :23272
  • Engelm M, Ansquer S, Dugast E, Bezard E, Belin D, Fernagut PO Multi-facetted impulsivity following nigral degenration and dopamine replacmeent therapy Neuropharmacology 2016 May 20
  • Arvaniti M, Jensen MJ, Soni N, Wang H, Klein AB, Thiriet N, Pinborg LH, Muldoon PP, Wienecke J, Damaj MI, Kohlmeier KA, Gondr.-Lewis MC, Mikkelsen JD, Thomsen MS Functional interaction between Lypd6 and nicotinic acetylcholine receptors 2016 accepted in Journal of Neuroschenistry .
  • Belujon P, Jakobowski NJ, Dollish HK, Grace AA ≪Withdrawal from acute amphetamine induces an amygdala-driven attenuation of dopamine neuron activity: reversal by ketamine. Neuropsychopharmacology. 2016 Jan;41(2):619-27.

2015

  • Ducret E, Puaud M, Lacoste J, BelinRauscent A, Fouyssac M, Dugast E, Murray JE, Everitt BJ, Houeto JL, Belin D N-acetylcysteine facilitates self-imposed abstinence after escalation of cocaine intake Biological Psychiatry 2015
  • Francois A, Julian A, Ragot S, Dugast E, Blanchard L, Brishoual S, Chassaing D, Page G, Paccalin M. ≪Inflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients withAlzheimer’s Disease during 24 Months of Follow-Up. PLoS One. 2015 Sep 22;10(9)
  • Julian A, Dugast E, Ragot S, Krolak-Salmon P, Berrut G, Dantoine T, Hommet C, Hanon O, Page G, Paccalin M.There is no correlation between peripheral inflammation and cognitive status at diagnosis in Alzheimer’s disease. Aging Clin Exp Res. 2015 Oct;27(5):589-94.

2014

  • Nader J, Rapino C, Gennequin B, Chavant F, Francheteau M, Makriyannis A, Duranti A, Maccarrone M, Solinas M, Thiriet N. Prior stimulation of the endocannabinoid system prevents methamphetamineinduced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. Neuropharmacology. 2014 Dec;87:214-21.
  • Chauvet C., Nicolas C, Thiriet N, Lardeux MV, Duranti A, Solinas M chronic stimulation of the tone endogenous anandamide reduces cue-and stress-induced relapse in rats International Journal of Neuropsychopharmacology 2014 Dec 5 ;18 (1)
  • Lepelletier FX, Tauber C, Nicolas C, Solinas M, Castelnau P, Belzung C, Emond P, Cortese, Faraone SV, Chalon S, Galineau L prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats Int J Neuropsychopharmaoclogy 2014 Oct 31 ; 18(4)
  • Ansquer S, Belin-Rauscent A, Dugast E, Duran T, Benatru I, Mar AC, Houeto JL, Belin D. Atomoxetine decreases vulnerability to develop compulsivity in high impulsive rats. Biological Psychiatry. 2014 May 15;75(10):825-32.
  • Belujon P, Patton, MH, Grace AA Role of the prefrontal cortex in altered hippocampal-accumbens synaptic plsticity in a developmental animal model of schizophrenia Cerebral Cortex. 2014 Apr;24(4):968-77.
  • Belujon P, Grace AA Restoring mood balance in depression : ketamine reverses deficits in dopaminedependent synaptic plqsticity≫ Biological Psychiatry. 2014 Dec 15;76(12):927-36.

2013

  • Panlilio LV, Zanettini C, Barnes C, Solinas M, Goldberg SR Prior exposure to THC increases the addictive effects of nicotine in rats Neuropsychopharmacology 2013 Jun ;38(7) :1198-208
  • Justinova Z1, Mascia P, Wu HQ, Secci ME, Redhi GH, Panlilio LV, Scherma M, Barnes C, Parashos A, Zara T, Fratta W, Solinas M, Pistis M, Bergman J, Kangas BD, Ferre S, Tanda G, Schwarcz R, Goldberg SR Reducing cannabinoid abuse and reventing relapse by enhancing endogenous brain levels of kynurenic acid Nature Neuroscience 2013 Nov;16(11):1652-61
  • Orru M, Guitart X, Karcz-Kubicha M, Solinas M, Justinova Z, Barodia SK, Zanoveli J, Cortes A, Lluis C, Casado V, Moeller FG, Ferre S. Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans. Neuropharmacology. 2013 Apr;67:476-84.
  • Massaly N1, Dahan L, Baudonnat M, Hovnanian C, Rekik K, Solinas M, David V, Pech S, Zajac JM, Roullet P, Mouledous L, Frances B Involvement of protein degradation by the ubiquitin proteasome system in opiate addictive behaviors. Neuropsychopharmacology. 2013 Mar;38(4):596-604.
  • Belujon P, Patton MH, Grace AA. Disruption of prefrontal cortical-hippocampal balance in a developmental model of s bchizophrenia : reversal by sulpiride International Journal of Neuropsychopharmacology 2013 Apr;16(3):507-12

2012

  • Decressac M, Pain S, Chabeauti PY, Frangeul L, Thiriet N, Herzog H, Vergote J, Chalon S, Jaber M, Gaillard A Neuroprotection by neuropeptide Y in cell and animal models of Parkinson’s disease Neurobioly of Aging 2012 Sep : 33(9)2125-37
  • De Luca MA, Solinas M, Bimpisidis Z, Goldberg SR, Di Chiara G. Cannabinoid facilitation of behavioral and biochemical hedonic taste responses. Neuropharmacology. 2012 Jul;63(1):161-8.
  • Chauvet C, Goldberg SR, Jaber M, Solinas M. Effects of environmental enrichment on the incubation of cocaine craving. Neuropharmacology. 2012 Sep;63(4):635-41.
  • Nader J, Chauvet C, Rawas RE, Favot L, Jaber M, Thiriet N, Solinas M Loss of environmental enrichment increases vulnerability to cocaine addiction Neuropsychopharmacology 2012 Jun ;37(7) : 1579-87
  • Lemaire V, Tronel S, Montaron MF, Fabre A, Dugast E, Abrous DN long-lasting plasticity of hippocampal adult-born neurons Journal of neurosciences 2012 Feb 29 :32(9) :3101-8
  • Couturier J, Paccalin M, Lafay-Chebassier C, Chalon S, Ingrand I, Pinguet J, Pontcharraud R, Guillard O, Fauconneau B, Page G. Pharmacological inhibition of PKR in APPswePS1dE9 mice transiently prevents inflammation at 12 months of age but increases Aβ42 levels in the late stages of the Alzheimer’s disease. Curr Alzheimer Res. 2012 Mar;9(3):344-60.

 


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