Peer-reviewed Articles


  • Nicolas C, Hofford RS, Dugast E, Lardeux V, Belujon P, Solinas M, Bardo MT, Thiriet N. Prevention of relapse to methamphetamine self-administration by environmental enrichment: involvement of glucocorticoid receptors. Psychopharmacology (Berl). 2021 Mar 25. doi: 10.1007/s00213-021-05770-6. Epub ahead of print. PMID: 33768375.
  • Solinas M, Chauvet C, Lafay-Chebassier C, Jaafari N, Thiriet N. Environmental enrichment-inspired pharmacological tools for the treatment of addiction. Curr Opin Pharmacol. 2021 Feb;56:22-28. doi: 10.1016/j.coph.2020.09.001. Epub 2020 Sep 20. PMID: 32966941.
  • Salin A, Lardeux V, Solinas M, Belujon P. Protracted Abstinence From Extended Cocaine Self-Administration Is Associated With Hypodopaminergic Activity in the VTA but Not in the SNc. Int J Neuropsychopharmacol. 2021 Jul 14;24(6):499-504. doi: 10.1093/ijnp/pyaa096. PMID: 33305794; PMCID: PMC8278795.


  • Salin A, Lardeux V, Solinas M, Belujon P. Protracted abstinence from extended cocaine self-administration is associated with hypodopaminergic activity in the VTA but not in the SNc. Int J Neuropsychopharmacol. 2020 Dec 11:pyaa096. doi: 10.1093/ijnp/pyaa096. Epub ahead of print. PMID: 33305794.
  • Solinas M, Chauvet C, Lafay-Chebassier C, Jaafari N, Thiriet N. Environmental enrichment-inspired pharmacological tools for the treatment of addiction. Curr Opin Pharmacol. 2020 Sep 20;56:22-28. doi: 10.1016/j.coph.2020.09.001. Epub ahead of print. PMID: 32966941.
  • Vanderkam P, Solinas M, Ingrand I, Doux N, Ebrahimighavam S, Jaafari N, Lafay-Chebassier C. Effectiveness of drugs acting on adrenergic receptors in the treatment for tobacco or alcohol use disorders: systematic review and meta-analysis. Addiction. 2020 Sep 22. doi: 10.1111/add.15265. Epub ahead of print. PMID: 32959918.
  • Dandaba M, Serra W, Harika-Germaneau G, Silvain C, Langbour N, Solinas M, Noël X, Jaafari N, Chatard A. Predicting relapse in patients with severe alcohol use disorder: The role of alcohol insight and implicit alcohol associations. Addict Behav. 2020 Aug;107:106433. doi: 10.1016/j.addbeh.2020.106433. Epub 2020 Apr 7. PMID: 32289744.


  • Solinas M, Belujon P, Fernagut PO, Jaber M, Thiriet N. Dopamine and addiction: what have we learned from 40 years of research. J Neural Transm (Vienna). 2019 Apr;126(4):481-516. doi: 10.1007/s00702-018-1957-2. Epub 2018 Dec 19. PMID: 30569209.


  • Alsebaaly J, Dugast E, Favot L, Rabbaa Khabbaz L, Solinas M, Thiriet N. “Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats.”Front Mol Neurosci. 2018 Dec 13;11:457. doi: 10.3389/fnmol.2018.00457. eCollection 2018.
  • Wahab M, Panlilio LV, Solinas M. “An improved within-session self-adjusting delay discounting procedure for the study of choice impulsivity in rats.”Psychopharmacology (Berl). 2018 Jul;235(7):2123-2135. doi: 10.1007/s00213-018-4911-y. Epub 2018 Apr 30
  • Ingrand I, Solinas M, Ingrand P, Dugast E, Saulnier PJ, Pérault-Pochat MC, Lafay-Chebassier C.« Lack of effects of simvastatin on smoking cessation in humans: A double-blind, randomized, placebo-controlled clinical study.” Sci Rep. 2018 Mar 1;8(1):3836. doi: 10.1038/s41598-018-21819-7


  • Sikora M, Nicolas C, Istin M, Jaafari N, Thiriet N, Solinas M.“Generalization of effects of environmental enrichment on seeking for different classes of drugs of abuse.”Behav Brain Res. 2018 Apr 2;341:109-113. doi: 10.1016/j.bbr.2017.12.027. Epub 2017 Dec 27
  • Nicolas C, Tauber C, Lepelletier FX, Chalon S, Belujon P, Galineau L, Solinas M. « Longitudinal Changes in Brain Metabolic Activity after Withdrawal from Escalation of Cocaine Self-Administration.” 2017 Sep;42(10):1981-1990. doi: 10.1038/npp.2017.109. Epub 2017 May 29.
  • Lafragette A, Bardo MT, Lardeux V, Solinas M, Thiriet N.“Reduction of Cocaine-Induced Locomotor Effects by Enriched Environment Is Associated with Cell-Specific Accumulation of ΔFosB in Striatal and Cortical Subregions.” Int J Neuropsychopharmacol. 2017 Mar 1;20(3):237-246. doi: 10.1093/ijnp/pyw097.



  • Chauvet C, Nicolas C, Lafay-chebassier C, Jaber M, Thiriet N, Solinas M ≪ Statins reduce the risks of relapse to addiction in rats ≫ Neuropsychopharmacology 2016 May ;41(6) :1588-97
  • Istin M, Thiriet N, Solinas M ≪ Behavioral flexibility predicts increased ability to resist excessive methamphetamine self-administration ≫ Addict Biol 2016 Mar 9
  • Nicolas C, Lafay-Chebassier, Solinas M ≪ exposure to sucrose during periods of withdrawal does not reduce cocaine-seeking in rats ≫ Scientific Report 2016 Mar21 ;6 :23272
  • Engelm M, Ansquer S, Dugast E, Bezard E, Belin D, Fernagut PO ≪ Multi-facetted impulsivity following nigral degenration and dopamine replacmeent therapy ≫ Neuropharmacology 2016 May 20
  • Arvaniti M, Jensen MJ, Soni N, Wang H, Klein AB, Thiriet N, Pinborg LH, Muldoon PP, Wienecke J, Damaj MI, Kohlmeier KA, Gondr.-Lewis MC, Mikkelsen JD, Thomsen MS ≪ Functional interaction between Lypd6 and nicotinic acetylcholine receptors ≫ 2016 accepted in Journal of Neuroschenistry .
  • Belujon P, Jakobowski NJ, Dollish HK, Grace AA ≪Withdrawal from acute amphetamine induces an amygdala-driven attenuation of dopamine neuron activity: reversal by ketamine. Neuropsychopharmacology. 2016 Jan;41(2):619-27.


  • Ducret E, Puaud M, Lacoste J, BelinRauscent A, Fouyssac M, Dugast E, Murray JE, Everitt BJ, Houeto JL, Belin D ≪ N-acetylcysteine facilitates self-imposed abstinence after escalation of cocaine intake ≫ Biological Psychiatry 2015
  • Francois A, Julian A, Ragot S, Dugast E, Blanchard L, Brishoual S, Chassaing D, Page G, Paccalin M. ≪Inflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients withAlzheimer’s Disease during 24 Months of Follow-Up. ≫ PLoS One. 2015 Sep 22;10(9)
  • Julian A, Dugast E, Ragot S, Krolak-Salmon P, Berrut G, Dantoine T, Hommet C, Hanon O, Page G, Paccalin M.There is no correlation between peripheral inflammation and cognitive status at diagnosis in Alzheimer’s disease. Aging Clin Exp Res. 2015 Oct;27(5):589-94.


  • Nader J, Rapino C, Gennequin B, Chavant F, Francheteau M, Makriyannis A, Duranti A, Maccarrone M, Solinas M, Thiriet N. ≪ Prior stimulation of the endocannabinoid system prevents methamphetamineinduced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. ≫ Neuropharmacology. 2014 Dec;87:214-21.
  • Chauvet C., Nicolas C, Thiriet N, Lardeux MV, Duranti A, Solinas M ≪ chronic stimulation of the tone endogenous anandamide reduces cue-and stress-induced relapse in rats ≫ International Journal of Neuropsychopharmacology 2014 Dec 5 ;18 (1)
  • Lepelletier FX, Tauber C, Nicolas C, Solinas M, Castelnau P, Belzung C, Emond P, Cortese, Faraone SV, Chalon S, Galineau L ≪ prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats ≫ Int J Neuropsychopharmaoclogy 2014 Oct 31 ; 18(4)
  • Ansquer S, Belin-Rauscent A, Dugast E, Duran T, Benatru I, Mar AC, Houeto JL, Belin D. ≪ Atomoxetine decreases vulnerability to develop compulsivity in high impulsive rats. ≫ Biological Psychiatry. 2014 May 15;75(10):825-32.
  • Belujon P, Patton, MH, Grace AA ≪ Role of the prefrontal cortex in altered hippocampal-accumbens synaptic plsticity in a developmental animal model of schizophrenia ≫ Cerebral Cortex. 2014 Apr;24(4):968-77.
  • Belujon P, Grace AA ≪ Restoring mood balance in depression : ketamine reverses deficits in dopaminedependent synaptic plqsticity≫ Biological Psychiatry. 2014 Dec 15;76(12):927-36.


  • Panlilio LV, Zanettini C, Barnes C, Solinas M, Goldberg SR ≪ Prior exposure to THC increases the addictive effects of nicotine in rats ≫ Neuropsychopharmacology 2013 Jun ;38(7) :1198-208
  • Justinova Z1, Mascia P, Wu HQ, Secci ME, Redhi GH, Panlilio LV, Scherma M, Barnes C, Parashos A, Zara T, Fratta W, Solinas M, Pistis M, Bergman J, Kangas BD, Ferre S, Tanda G, Schwarcz R, Goldberg SR ≪ Reducing cannabinoid abuse and reventing relapse by enhancing endogenous brain levels of kynurenic acid ≫ Nature Neuroscience 2013 Nov;16(11):1652-61
  • Orru M, Guitart X, Karcz-Kubicha M, Solinas M, Justinova Z, Barodia SK, Zanoveli J, Cortes A, Lluis C, Casado V, Moeller FG, Ferre S. ≪ Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans. ≫ Neuropharmacology. 2013 Apr;67:476-84.
  • Massaly N1, Dahan L, Baudonnat M, Hovnanian C, Rekik K, Solinas M, David V, Pech S, Zajac JM, Roullet P, Mouledous L, Frances B ≪ Involvement of protein degradation by the ubiquitin proteasome system in opiate addictive behaviors. ≫ Neuropsychopharmacology. 2013 Mar;38(4):596-604.
  • Belujon P, Patton MH, Grace AA. ≪ Disruption of prefrontal cortical-hippocampal balance in a developmental model of s bchizophrenia : reversal by sulpiride ≫ International Journal of Neuropsychopharmacology 2013 Apr;16(3):507-12


  • Decressac M, Pain S, Chabeauti PY, Frangeul L, Thiriet N, Herzog H, Vergote J, Chalon S, Jaber M, Gaillard A ≪ Neuroprotection by neuropeptide Y in cell and animal models of Parkinson’s disease ≫ Neurobioly of Aging 2012 Sep : 33(9)2125-37
  • De Luca MA, Solinas M, Bimpisidis Z, Goldberg SR, Di Chiara G. ≪ Cannabinoid facilitation of behavioral and biochemical hedonic taste responses. ≫ Neuropharmacology. 2012 Jul;63(1):161-8.
  • Chauvet C, Goldberg SR, Jaber M, Solinas M. ≪ Effects of environmental enrichment on the incubation of cocaine craving. ≫ Neuropharmacology. 2012 Sep;63(4):635-41.
  • Nader J, Chauvet C, Rawas RE, Favot L, Jaber M, Thiriet N, Solinas M ≪ Loss of environmental enrichment increases vulnerability to cocaine addiction ≫ Neuropsychopharmacology 2012 Jun ;37(7) : 1579-87
  • Lemaire V, Tronel S, Montaron MF, Fabre A, Dugast E, Abrous DN ≪ long-lasting plasticity of hippocampal adult-born neurons ≫ Journal of neurosciences 2012 Feb 29 :32(9) :3101-8
  • Couturier J, Paccalin M, Lafay-Chebassier C, Chalon S, Ingrand I, Pinguet J, Pontcharraud R, Guillard O, Fauconneau B, Page G. ≪ Pharmacological inhibition of PKR in APPswePS1dE9 mice transiently prevents inflammation at 12 months of age but increases Aβ42 levels in the late stages of the Alzheimer’s disease. ≫ Curr Alzheimer Res. 2012 Mar;9(3):344-60.


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