ICHAS François

EQUIPE de rattachement : Equipe 3 (M. Jaber/P. O. Fernagut)

NOM Prénom : ICHAS François

Statut : DR2 INSERM

Adresse :  Pôle Biologie Santé – B36 1, rue Georges Bonnet TSA 51106 86073 POITIERS CEDEX 9

Tél :

e-mail : francois.ichas@inserm.fr

Publications (toutes les marquantes, y compris avant 2012)

1.       Rey C, Faustin B, Mahouche I, Ruggieri R, Brulard C, Ichas F, Soubeyran I, Lartigue L, De Giorgi F. The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer. Oncogene. 2016 Jun 16;35(24):3190-200.

2.       Winckler P, Lartigue L, Giannone G, De Giorgi F, Ichas F, Sibarita JB, Lounis  B, Cognet L. Identification and super-resolution imaging of ligand-activated receptor dimers in live cells. Sci Rep. 2013;3:2387.

3.       Rey C, Soubeyran I, Mahouche I, Pedeboscq S, Bessede A, Ichas F, De Giorgi F,  Lartigue L. HIPK1 drives p53 activation to limit colorectal cancer cell growth. Cell Cycle. 2013 Jun 15;12(12):1879-91.

4.       Pédeboscq S, Rey C, Petit M, Harpey C, De Giorgi F, Ichas F, Lartigue L. Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro. PLoS One. 2012;7(5):e36811.

5.       Auzanneau C, Montaudon D, Jacquet R, Puyo S, Pouységu L, Deffieux D, Elkaoukabi-Chaibi A, De Giorgi F, Ichas F, Quideau S, Pourquier P. The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II. Mol Pharmacol. 2012 Jul;82(1):134-41.

6.       Soubeyran I, Mahouche I, Grigoletto A, Leste-Lasserre T, Drutel G, Rey C, Pedeboscq S, Blanchard F, Brouste V, Sabourin JC, Bécouarn Y, Reiffers J, Ichas F, De Giorgi F. Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function. Am J Pathol. 2011 May;178(5):1986-98.

7.       Schembri L, Zanese M, Depierre-Plinet G, Petit M, Elkaoukabi-Chaibi A, Tauzin L, Florean C, Lartigue L, Medina C, Rey C, Belloc F, Reiffers J, Ichas F, De Giorgi F. Recombinant differential anchorage probes that tower over the spatial dimension of intracellular signals for high content screening and analysis. Anal  Chem. 2009 Dec 1;81(23):9590-8.

8.       Tomasello F, Messina A, Lartigue L, Schembri L, Medina C, Reina S, Thoraval D, Crouzet M, Ichas F, De Pinto V, De Giorgi F. Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis. Cell Res. 2009 Dec;19(12):1363-76.

9.       Lartigue L, Medina C, Schembri L, Chabert P, Zanese M, Tomasello F, Dalibart  R, Thoraval D, Crouzet M, Ichas F, De Giorgi F. An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis. J Cell  Sci. 2008 Nov 1;121(Pt 21):3515-23.

10.     Dupret D, Revest JM, Koehl M, Ichas F, De Giorgi F, Costet P, Abrous DN, Piazza PV. Spatial relational memory requires hippocampal adult neurogenesis. PLoS One. 2008 Apr 9;3(4):e1959.

11.     Florean C, Zampese E, Zanese M, Brunello L, Ichas F, De Giorgi F, Pizzo P. High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer’s disease. Biochim Biophys Acta. 2008 Aug;1783(8):1551-60.

12.     Jaubert A, Drutel G, Leste-Lasserre T, Ichas F, Bresson-Bepoldin L. Tyrosine  hydroxylase and dopamine transporter expression in lactotrophs from postlactating rats: involvement in dopamine-induced apoptosis. Endocrinology. 2007 Jun;148(6):2698-707.

13.     Schembri L, Dalibart R, Tomasello F, Legembre P, Ichas F, De Giorgi F. The HA tag is cleaved and loses immunoreactivity during apoptosis. Nat Methods. 2007 Feb;4(2):107-8. PubMed PMID: 17264856.

14.     Jaubert A, Ichas F, Bresson-Bepoldin L. Signaling pathway involved in the pro-apoptotic effect of dopamine in the GH3 pituitary cell line. Neuroendocrinology. 2006;83(2):77-88.

15.     Ichas F, Jouaville LS, Mazat JP. Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell. 1997 Jun 27;89(7):1145-53.

16.     Jouaville LS, Ichas F, Holmuhamedov EL, Camacho P, Lechleiter JD. Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes. Nature. 1995 Oct 5;377(6548):438-41.


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