EQUIPE de rattachement : Equipe 3 (M. Jaber/P. O. Fernagut)

NOM Prénom : DE GIORGI-ICHAS Francesca

Statut : CR1 INSERM

Adresse :  Pôle Biologie Santé – B36 1, rue Georges Bonnet TSA 51106 86073 POITIERS CEDEX 9

Tél :

e-mail : francesca.degiorgi-ichas@inserm.fr

Publications (toutes les marquantes, y compris avant 2012)

1.       Rey C, Faustin B, Mahouche I, Ruggieri R, Brulard C, Ichas F, Soubeyran I, Lartigue L, De Giorgi F. The MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer. Oncogene. 2016 Jun 16;35(24):3190-200.

2.       Winckler P, Lartigue L, Giannone G, De Giorgi F, Ichas F, Sibarita JB, Lounis  B, Cognet L. Identification and super-resolution imaging of ligand-activated receptor dimers in live cells. Sci Rep. 2013;3:2387.

3.       Rey C, Soubeyran I, Mahouche I, Pedeboscq S, Bessede A, Ichas F, De Giorgi F,  Lartigue L. HIPK1 drives p53 activation to limit colorectal cancer cell growth. Cell Cycle. 2013 Jun 15;12(12):1879-91.

4.       Pédeboscq S, Rey C, Petit M, Harpey C, De Giorgi F, Ichas F, Lartigue L. Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro. PLoS One. 2012;7(5):e36811.

5.       Auzanneau C, Montaudon D, Jacquet R, Puyo S, Pouységu L, Deffieux D, Elkaoukabi-Chaibi A, De Giorgi F, Ichas F, Quideau S, Pourquier P. The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II. Mol Pharmacol. 2012 Jul;82(1):134-41.

6.       Soubeyran I, Mahouche I, Grigoletto A, Leste-Lasserre T, Drutel G, Rey C, Pedeboscq S, Blanchard F, Brouste V, Sabourin JC, Bécouarn Y, Reiffers J, Ichas F, De Giorgi F. Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function. Am J Pathol. 2011 May;178(5):1986-98.

7.       Schembri L, Zanese M, Depierre-Plinet G, Petit M, Elkaoukabi-Chaibi A, Tauzin L, Florean C, Lartigue L, Medina C, Rey C, Belloc F, Reiffers J, Ichas F, De Giorgi F. Recombinant differential anchorage probes that tower over the spatial dimension of intracellular signals for high content screening and analysis. Anal  Chem. 2009 Dec 1;81(23):9590-8.

8.       Tomasello F, Messina A, Lartigue L, Schembri L, Medina C, Reina S, Thoraval D, Crouzet M, Ichas F, De Pinto V, De Giorgi F. Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis. Cell Res. 2009 Dec;19(12):1363-76.

9.       Lartigue L, Medina C, Schembri L, Chabert P, Zanese M, Tomasello F, Dalibart  R, Thoraval D, Crouzet M, Ichas F, De Giorgi F. An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis. J Cell  Sci. 2008 Nov 1;121(Pt 21):3515-23.

10.     Dupret D, Revest JM, Koehl M, Ichas F, De Giorgi F, Costet P, Abrous DN, Piazza PV. Spatial relational memory requires hippocampal adult neurogenesis. PLoS One. 2008 Apr 9;3(4):e1959.

11.     Florean C, Zampese E, Zanese M, Brunello L, Ichas F, De Giorgi F, Pizzo P. High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer’s disease. Biochim Biophys Acta. 2008 Aug;1783(8):1551-60.

12.     Schembri L, Dalibart R, Tomasello F, Legembre P, Ichas F, De Giorgi F. The HA tag is cleaved and loses immunoreactivity during apoptosis. Nat Methods. 2007 Feb;4(2):107-8. PubMed PMID: 17264856.

13.     1: Zaccolo M, De Giorgi F, Cho CY, Feng L, Knapp T, Negulescu PA, Taylor SS, Tsien RY, Pozzan T. A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol. 2000 Jan;2(1):25-9. PubMed PMID: 10620803.

14.      De Giorgi F, Ahmed Z, Bastianutto C, Brini M, Jouaville LS, Marsault R, Murgia M, Pinton P, Pozzan T, Rizzuto R. Targeting GFP to organelles. Methods Cell Biol. 1999;58:75-85. Review. PubMed PMID: 9891375.

15.     Rizzuto R, Brini M, De Giorgi F, Rossi R, Heim R, Tsien RY, Pozzan T. Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo. Curr Biol. 1996 Feb 1;6(2):183-8. PubMed PMID: 8673465.

16.     De Giorgi F, Brini M, Bastianutto C, Marsault R, Montero M, Pizzo P, Rossi R, Rizzuto R. Targeting aequorin and green fluorescent protein to intracellular organelles. Gene. 1996;173(1 Spec No):113-7. PubMed PMID: 8707049.

17.     Bastianutto C, Clementi E, Codazzi F, Podini P, De Giorgi F, Rizzuto R, Meldolesi J, Pozzan T. Overexpression of calreticulin increases the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of their luminal microenvironment and function. J Cell Biol. 1995 Aug;130(4):847-55. PubMed PMID: 7642702; PubMed Central PMCID: PMC2199966.


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