Non classé


  • Tareq Al Sagheer, Obelia Haida, Anais Balbous, Maureen Francheteau, Emmanuel Matas, Pierre-Olivier Fernagut, Mohamed Jaber; Motor impairments correlate with social deficits and restricted neuronal loss in an environmental model of autism, International Journal of Neuropsychopharmacology, , pyy043,



  • Chauvet C, Nicolas C, Lafay-chebassier C, Jaber M, Thiriet N, Solinas M « Statins reduce the risks of relapse to addiction in rats » Neuropsychopharm. 2016 May ;41(6) :1588-97.


  • Bassil F, Monvoisin A, Canron MH, Vital A, Meissner WG, Tison F, Fernagut PO: Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy. Mov Disord 2015; 30:1802-12,
  • Bourdenx M, Dovero S, Engeln M, Bido S, Bastide MF, Dutheil N, Vollenweider I, Baud L, Piron C, Grouthier V, Boraud T, Porras G, Li Q, Baekelandt V, Scheller D, Michel A, Fernagut PO, Georges F, Courtine G, Bezard E, Dehay B: Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression. Acta Neuropathol Commun 2015; 3: 46
  • Engeln M, De Deurwaerdere P, Li Q, Bezard E, Fernagut PO: Widespread Monoaminergic Dysregulation of Both Motor and Non-Motor Circuits in Parkinsonism and Dyskinesia. Cereb Cortex 2015; 25: 2783-92
  • Arcuri L, Viaro R, Bido S, Longo F, Calcagno M, Fernagut PO, Zaveri NT, Calo G, Bezard E, Morari M: Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson’s disease. Neurobiol Dis 2016; 89: 55-64
  • Bastide MF, de la Crompe B, Doudnikoff E, Fernagut PO, Gross CE, Mallet N, Boraud T, Bezard E:Inhibiting Lateral Habenula Improves L-DOPA-Induced Dyskinesia. Biol Psychiatry 2016; 79: 345-53
  • Engeln M, Ansquer S, Dugast E, Bezard E, Belin D, Fernagut PO. Multi-facetted impulsivity following nigral degeneration and dopamine replacement therapy. Neuropharmacology 2016; 109: 69-77
  • Engeln M, Bastide MF, Toulme E, Dehay B, Bourdenx M, Doudnikoff E, Li Q, Gross CE, Boue-Grabot E, Pisani A, Bezard E, Fernagut PO. Selective Inactivation of Striatal FosB/DeltaFosB-Expressing Neurons Alleviates L-DOPA-Induced Dyskinesia. Biol Psychiatry 2016; 79: 354-61
  • Rey C, Faustin B, Mahouche I, Ruggieri R, Brulard C, Ichas F, Soubeyran I, Lartigue L, De Giorgi F. « The
    MAP3K ZAK, a novel modulator of ERK-dependent migration, is upregulated in colorectal cancer. » Oncogene. 2016 Jun 16;35(24):3190-200.
  • Bassil F, Fernagut PO, Bezard E, Pruvost A, Leste-Lasserre T, Hoang Q, Ringe D, Petsko GA, Meissner WG.
    « Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy. » Proceedings of National Academy of Sciences USA 2016 (in


  • Vitrac C, Péron S, Frappé I, Fernagut P-O, Jaber M, Gaillard A, Benoit-Marand M. « Dopamine control of pyramidal neuron activity in the primary motor cortex via D2 receptors. » Front Neural Circuits 2014 Feb 28;8:13.
  • Bastide MF, Dovero S, Charron G, Porras G, Gross CE, Fernagut PO, Bezard E: Immediate-early gene expression in structures outside the basal ganglia is associated to l-DOPA-induced dyskinesia. Neurobiol Dis 2014; 62: 179-92
  • Fernagut PO, Meissner WG, Biran M, Fantin M, Bassil F, Franconi JM, Tison F: Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy. Synapse 2014; 68: 98-106
  • Flabeau O, Meissner WG, Ozier A, Berger P, Tison F, Fernagut PO: Breathing variability and brainstem serotonergic loss in a genetic model of multiple system atrophy. Mov Disord 2014; 29: 388-95
  • Recasens A, Dehay B, Bove J, Carballo-Carbajal I, Dovero S, Perez-Villalba A, Fernagut PO, Blesa J, Parent A, Perier C, Farinas I, Obeso JA, Bezard E, Vila M: Lewy body extracts from Parkinson disease brains trigger alpha-synuclein pathology and neurodegeneration in mice and monkeys. Ann Neurol 2014; 75:351-62
  • Houédé N, Pulido M, Mourey L, Joly F, Ferrero JM, Bellera C, Priou F, Lalet C, Laroche-Clary A, Raffin MC, Ichas F, Puech A, Piazza PV. « A phase II trial evaluating the efficacy and safety of efavirenz in metastatic castration-resistant prostate cancer. » Oncologist. 2014 Dec;19(12):1227-8.


  • Saha B, Peron S, Murray K, Jaber M, Gaillard A. Cortical lesion stimulates adult subventricular zone neural progenitor cell proliferation and migration to the site of injury. Stem Cell Res. 2013 Jun 24;11(3):965-977
  • Engeln M, Ahmed SH, Vouillac C, Tison F, Bezard E, Fernagut PO: Reinforcing properties of Pramipexole
    in normal and parkinsonian rats. Neurobiol Dis 2013; 49: 79-86 18. Engeln M, Fasano S, Ahmed SH, Cador M, Baekelandt V, Bezard E, Fernagut PO: Levodopa gains psychostimulant-like properties after nigral dopaminergic loss. Ann Neurol 2013; 74: 140-4
  • Winckler P, Lartigue L, Giannone G, De Giorgi F, Ichas F, Sibarita JB, Lounis B, Cognet L. « Identification
    and super-resolution imaging of ligand-activated receptor dimers in live cells. » Sci Rep. 2013;3:2387.
  • Rey C, Soubeyran I, Mahouche I, Pedeboscq S, Bessede A, Ichas F, De Giorgi F, Lartigue L. « HIPK1 drives
    p53 activation to limit colorectal cancer cell growth. » Cell Cycle. 2013 Jun 15;12(12):1879-91


  • Nader J, El Rawas R, Chauvet C, Jaber M, Thiriet N, Solinas M. Loss of environmental enrichment increases vulnerability to cocaine addiction. Neuropsychopharmacology. 2012; 37(7): 1579-87.
  • Decressac M, Pain S, Chabeauti P-Y, Frangeul L, Thiriet N, Herzog H, Vergote J, Chalon S, Jaber M, Gaillard A. Neuroprotection by neuropeptide Y in cell and animal models of Parkinson’s disease. Neurobiol Aging. 2012; 33(9): 2125–37.
  • Chauvet C, Goldberg S R, Jaber M, Solinas M. Effects of environmental enrichment on the incubation of cocaine craving. Neuropharmacology. 2012; 63(4): 635-41.
  • Fernagut PO, Vital A, Canron MH, Tison F, Meissner WG: Ambiguous mechanisms of dysphagia in
    multiple system atrophy. Brain 2012; 135: e205; author reply e206
  • Pédeboscq S, Gravier D, Casadebaig F, Hou G, Gissot A, Rey C, Ichas F, De Giorgi F, Lartigue L, Pometan JP. « Synthesis and evaluation of apoptosis induction of thienopyrimidine compounds on KRAS and BRAF mutated colorectal cancer cell lines. » Bioorg Med Chem. 2012 Nov 15;20(22):6724-31.
  • Pédeboscq S, Rey C, Petit M, Harpey C, De Giorgi F, Ichas F, Lartigue L. « Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro. » PLoS One. 2012;7(5):e36811.
  • Auzanneau C, Montaudon D, Jacquet R, Puyo S, Pouységu L, Deffieux D, Elkaoukabi-Chaibi A, De Giorgi F, Ichas F, Quideau S, Pourquier P. « The polyphenolic ellagitannin vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II. » Mol Pharmacol. 2012 Jul;82(1):134-41.


  • Decressac M, Pain S, Chabeauti PY, Frangeul L, Thiriet N, Herzog H, Vergote J, Chalon S, Jaber M, Gaillard A Neuroprotection by neuropeptide Y in cell and animal models of Parkinson’s disease. Neurobiol Aging. 2012 Sep;33(9):2125-37.
  • Chauvet C, Lardeux V, Jaber M, Solinas M. Brain regions associated with the reversal of cocaine conditioned place preference by environmental enrichment. Neuroscience. 2011 Jun 16;184:88-96.
  • El Rawas R, Thiriet N, Nader J, Lardeux V, Jaber M, Solinas M. Early exposure to environmental enrichment alters the expression of genes of the endocannabinoid system. Brain Res. 2011 May 16;1390:80-9.
  • Thiriet N, Agasse F, Nicoleau C, Guégan C, Vallette F, Cadet JL, Jaber M, Malva JO, Coronas V. NPY promotes chemokinesis and neurogenesis in the rat subventricular zone. J Neurochem. 2011 Mar;116(6):1018-27.
  • Thiriet N, Gennequin B, Lardeux V, Chauvet C, Decressac M, Janet T, Jaber M, Solinas M. Environmental enrichment does not reduce the rewarding and neurotoxic effects of methamphetamine. Neurotox Res. 2011 Jan;19(1):172-82.
  • Decressac M, Wright B, David B, Tyers P, Jaber M, Barker RA, Gaillard A. Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis. Hippocampus. 2011 Mar;21(3):233-8.
  • Fernagut PO. Links between glucocerebrosidase and alpha-synuclein revealed. Mov Disord. 2011 Oct;26(12):2177.
  • Fantin M, Morari M, Tison F, Fernagut PO. NR2B subunit blockade does not affect motor symptoms induced by 3-nitropropionic acid. Neurol Res. 2011 May;33(4):444-7.
  • Leger F, Fernagut PO, Canron MH, Léoni S, Vital C, Tison F, Bezard E, Vital A. Protein aggregation in the aging retina. J Neuropathol Exp Neurol. 2011 Jan;70(1):63-8.
  • Soubeyran I, Mahouche I, Grigoletto A, Leste-Lasserre T, Drutel G, Rey C, Pedeboscq S, Blanchard F, Brouste V, Sabourin JC, Bécouarn Y, Reiffers J, Ichas F, De Giorgi F. Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function. Am J Pathol. 2011 May;178(5):1986-98.
  • Annibale B, Maconi G, Lahner E, De Giorgi F, Cuomo R. Efficacy of Lactobacillus paracasei sub. paracasei F19 on abdominal symptoms in patients with symptomatic uncomplicated diverticular disease: a pilot study. Minerva Gastroenterol Dietol. 2011 Mar;57(1):13-22.
  • Compare D, Pica L, Rocco A, De Giorgi F, Cuomo R, Sarnelli G, Romano M, Nardone G. Effects of long-term PPI treatment on producing bowel symptoms and SIBO. Eur J Clin Invest. 2011 Apr;41(4):380-6.